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Associated factors of umbilical cord blood collection quality
Author(s) -
Faivre Lionel,
Couzin Chloé,
Boucher Hélène,
Domet Thomas,
Desproges André,
Sibony Olivier,
Bechard Marina,
Vanneaux Valérie,
Larghero Jérôme,
Cras Audrey
Publication year - 2018
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.14447
Subject(s) - umbilical cord , medicine , cord blood , haematopoiesis , placenta , blood collection , pregnancy , placenta cord banking , obstetrics , peripheral blood , stem cell , blood volume , immunology , intensive care medicine , fetus , biology , emergency medicine , genetics
After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection.