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Age of platelet concentrates and time to the next transfusion
Author(s) -
CaramDeelder Camila,
van der Bom Johanna G.,
Putter Hein,
Leyte Anja,
Kerkhof Daan van de,
Evers Dorothea,
Beckers Erik A.,
Weerkamp Floor,
Hudig Francisca,
Zwaginga Jaap Jan,
Rondeel Jan M.M.,
de Vooght Karen M.K.,
Péquériaux Nathalie C.V.,
Visser Otto,
Wallis Jonathan P.,
Middelburg Rutger A.
Publication year - 2018
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.14388
Subject(s) - medicine , apheresis , buffy coat , confidence interval , platelet , cohort , platelet transfusion , blood transfusion , surgery
BACKGROUND Storage time of platelet (PLT) concentrates has been negatively associated with clinical efficacy outcomes. The aim of this study was to quantify the association between storage time of PLT concentrates and interval to the next PLT transfusion for different types of PLT components, stored for up to 7 days and transfused to transfusion‐dependent hematooncology patients with thrombocytopenia. STUDY DESIGN AND METHODS From a cohort of patients from 10 major Dutch hospitals, patients were selected whose transfusion patterns were compatible with PLT transfusion dependency due to hematooncologic disease. Mean time to the next transfusion and mean differences in time to the next transfusion for different storage time categories (i.e., fresh, <4 days; intermediate, 4‐5 days; and old, >5 days) were estimated, per component type, using multilevel mixed‐effects linear models. RESULTS Among a cohort of 29,761 patients who received 140,896 PLT transfusions we selected 4441 hematooncology patients who had received 12,724 PLT transfusions during periods of PLT transfusion dependency. Transfusion of fresh, compared to old, buffy coat–derived PLTs in plasma was associated with a delay to the next transfusion of 6.2 hours (95% confidence interval [CI], 4.5‐8.0 hr). For buffy coat–derived PLTs in PAS‐B and ‐C this difference was 7.7 hours (95% CI, 2.2‐13.3 hr) and 3.9 hours (95% CI, –2.1 to 9.9 hr) while for apheresis PLTs in plasma it was only 1.8 hours (95% CI, –3.5 to 7.1 hr). CONCLUSION Our results indicate that the time to the next transfusion shortens with increasing age of transfused buffy coat–derived PLT concentrates. This association was not observed for apheresis PLTs.