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Autologous intrauterine transfusion in a case of anti‐U
Author(s) -
Adam Sumaiya,
Lombaard Hennie
Publication year - 2016
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.13806
Subject(s) - medicine , fetus , exchange transfusion , pregnancy , gestation , hemolytic disease of the newborn (abo) , blood transfusion , obstetrics , blood type (non human) , pediatrics , surgery , immunology , abo blood group system , genetics , biology
BACKGROUND Minor red blood cell antibodies are becoming a more common cause of hemolytic disease of the newborn. Anti‐U are a rare alloantibody found almost exclusively in people of black descent. There is limited experience to guide the management of pregnancies complicated by anti‐U. Furthermore, there is often no suitable cross‐matched blood available for transfusion of a patient with anti‐U. CASE REPORT A 21‐year‐old P0G1 presented at 25 weeks' gestation with D– disease in pregnancy. She had a significant indirect antiglobulin test titer of 512. Anti‐U were identified and no suitable cross‐matched blood was available. Maternal blood was prepared for autologous intrauterine fetal transfusion. Two such transfusions were performed. RESULTS A healthy fetus delivered at 32 weeks that did not require phototherapy or an exchange transfusion. CONCLUSION Autologous transfusion of prepared maternal blood provides a safe option for intrauterine fetal therapy in pregnancies complicated by rare alloantibodies.