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Comparing the ratio of mean red blood cell transfusion episode rate of 1 unit versus 2 units in hematopoietic stem cell transplant patients
Author(s) -
Avdić Aldijana,
Tucker Sharon,
Evans Rhonda,
Smith Anne,
Zimmerman M. Bridget
Publication year - 2016
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.13708
Subject(s) - medicine , hematopoietic stem cell transplantation , blood transfusion , intensive care unit , red blood cell , retrospective cohort study , surgery , transplantation
BACKGROUND Two units of red blood cells (RBCs) were typically transfused with each transfusion among hematopoietic stem cell transplant (HSCT) patients. Concerns regarding this practice are increased morbidity, mortality, hospital‐acquired infections, length of stay (LOS), and transfusion‐related complications. This study compared outcomes of transfusing 1 unit of RBCs per transfusion episode to 2 units of RBCs per episode among HSCT patients. STUDY DESIGN AND METHODS A retrospective record review was used to evaluate a practice change of transfusing 1 RBC unit per episode among autologous and allogeneic HSCT patients. Primary endpoints included: 1) mean number of RBC transfusion episodes during the hospital stay, 2) mean number of RBC units transfused adjusted by LOS, and 3) mean LOS. RESULTS Among autologous patients, the ratio of mean rate of transfusion episodes for transfusing 1 unit versus 2 units per transfusion was 1.24, with a one‐tailed 95% upper limit of 1.42. With a noninferiority upper bound of 1.50, using 1 unit per transfusion episode was noninferior to 2 units per transfusion episode (p = 0.011). Among allogeneic HSCT patients, the ratio of mean transfusion episode rate was 1.26 with a one‐tailed 95% upper limit of 1.52, which was slightly above the 1.50 noninferiority bound (p = 0.061). CONCLUSION A single‐unit transfusion policy was not inferior to the 2‐unit policy for autologous HSCT patients and trended toward noninferiority for allogeneic transplant patients. The mean volume of blood per LOS was lower for the 1‐unit practice for both groups. The gains from the practice change may outweigh the risks of not changing.