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Anti‐Mur as the most likely cause of mild hemolytic disease of the newborn
Author(s) -
Bakhtary Sara,
Gikas Anastasia,
Glader Bertil,
Andrews Jennifer
Publication year - 2016
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.13552
Subject(s) - hemolytic disease of the newborn (abo) , vietnamese , medicine , hemolytic anemia , disease , jaundice , antibody , anemia , population , immunology , immune system , pediatrics , pregnancy , biology , fetus , genetics , environmental health , linguistics , philosophy
BACKGROUND Although rare in the United States, anti‐Mur is relatively common in Southeast Asia and has been reported to have clinical significance in Chinese and Taiwanese populations. STUDY DESIGN AND METHODS The infant was full term and the second child of a Chinese mother and Vietnamese father, presenting with jaundice. He was clinically diagnosed with immune‐mediated hemolytic anemia. RESULTS The direct antiglobulin test indicated that the infant's red blood cells were coated only with anti‐IgG. Anti‐Mur was identified in the maternal serum and the neonate's plasma. The father was found to be positive for the Mur antigen. The cause of the infant's hemolytic anemia was determined to be most likely anti‐Mur. CONCLUSION Since anti‐Mur is implicated in causing hemolytic disease of the newborn, it is important to recognize this antibody more commonly found in Asian patients in the United States as the Mur+ phenotype has a higher prevalence in this population.