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Efficacy of plasmapheresis for the treatment of pure red blood cell aplasia after allogeneic stem cell transplantation
Author(s) -
Dellacasa Chiara Maria,
D'Ardia Stefano,
Allione Bernardino,
Aydin Semra,
Tassi Valter,
Francisci Tiziana,
Pecoraro Clara,
Busca Alessandro
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.13269
Subject(s) - pure red cell aplasia , abo blood group system , aplasia , medicine , plasmapheresis , transplantation , stem cell , complication , bone marrow aplasia , immunology , apheresis , bone marrow , surgery , biology , antibody , platelet , genetics
BACKGROUND Pure red blood cell aplasia (PRCA) is a complication of ABO major‐incompatible stem cell transplantation, likely due to the persistence of memory B lymphocytes of recipient origin, which produce hemagglutinins against ABO antigens on donor RBCs. At present no standard of care is established for this complication. CASE REPORT We report a case of PRCA after allogeneic bone marrow transplantation, successfully treated with plasma exchange (PEX) after failing erythropoietin administration. RESULTS The patient fully recovered from RBC aplasia. CONCLUSION This case suggests a role for PEX in the treatment of PRCA after allogeneic stem cell transplantation.