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Association of ABO blood group with P‐selectin levels in Chinese Han healthy volunteers
Author(s) -
Chen Ying,
Zhuo Xiaofu,
Lin Yisheng,
Huang Wenhua,
Xiao Jingrong,
Zeng Jia,
Jiang Li,
Chen Cen,
Lin Haijuan,
Dettke Markus
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.13212
Subject(s) - abo blood group system , genotype , phenotype , genotyping , biology , population , immunology , genetics , gene , medicine , environmental health
BACKGROUND Recent genome‐wide association studies in Caucasians suggested that an association exists between the ABO gene locus and soluble levels of P‐selectin (sP‐selectin). However, it is unclear if the relationship corresponds to the phenotypic expression of ABO groups or is present in different ethnic groups. The aim of this study was to verify this observation at both genotypic and phenotypic levels in a healthy Chinese population. STUDY DESIGN AND METHODS The ABO blood groups were determined by both phenotypes and genotypes in 440 healthy Chinese Han volunteers, while P‐selectin levels were evaluated for sP‐selectin and total platelet P‐selectin (pP‐selectin). RESULTS ABO phenotyping and quantitative analysis of individual sP‐selectin plasma levels were combined to demonstrate that individuals phenotypically expressing the A antigen have approximately 20% lower sP‐selectin plasma levels than those carrying the B or O phenotype (p < 0.0001), but that no difference exists between A and AB and between B and O phenotypes. Genotyping data revealed that the presence of the A gene could be attributed to the observed difference in phenotype comparison, with no difference between A/A, A/B, and A/O genotypes. There were also no associations between ABO blood groups, either phenotypes or genotypes, and pP‐selectin levels. CONCLUSION This study demonstrated an association between sP‐selectin levels and ABO groups in a Chinese Han population, implicating its generalizability to other ethnic groups. This finding will improve the understanding of the mechanism of ABO blood group–associated diseases.