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No association between iron status and self‐reported health‐related quality of life in 16,375 Danish blood donors: results from the Danish Blood Donor Study
Author(s) -
Rigas Andreas S.,
Pedersen Ole B.,
Sørensen Cecilie J.,
Sørensen Erik,
Kotzé Sebastian R.,
Petersen Mikkel S.,
Thørner Lise W.,
Hjalgrim Henrik,
Erikstrup Christian,
Ullum Henrik
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.13085
Subject(s) - medicine , danish , logistic regression , ferritin , anemia , quality of life (healthcare) , percentile , body mass index , national health and nutrition examination survey , mental health , health related quality of life , blood donor , iron deficiency , gerontology , environmental health , immunology , psychiatry , population , disease , philosophy , linguistics , statistics , nursing , mathematics
BACKGROUND Health‐related quality of life (HRQL) represents people's subjective assessment of their mental and physical well‐being. HRQL is highly predictive of future health. The effect of iron deficiency without anemia induced by blood donation on HRQL is presently unknown. The aim was to explore the relationship between iron status and self‐reported mental component score (MCS; SF‐12) and physical component score (PCS; SF‐12) in Danish blood donors. STUDY DESIGN AND METHODS Complete relevant data, including the 12‐item short‐form health survey (SF‐12), plasma ferritin levels, age, body mass index, smoking status, C‐reactive protein levels, number of donations in the previous 3 years, and PCS and MCS, were available for 8692 men and 7683 women enrolled from March 1, 2010, to December 31, 2010. Multivariable linear and logistic (cutoff at the 10th percentile) regression analyses were used to assess the relationship between iron deficiency (ferritin < 15 ng/mL) and MCS and PCS, respectively. Analyses were performed separately for men and women. RESULTS There was no significant relationship between iron deficiency and self‐reported mental or physical health. CONCLUSION This study found no association between iron stores and self‐reported HRQL among Danish blood donors.