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Iron depletion with a novel apheresis system in patients with hemochromatosis
Author(s) -
Grabmer Christoph,
Schmid Doris,
Mayer Georg,
Aigner Elmar,
Wagner Andrej,
Streif Doris,
Schallmoser Katharina,
Rohde Eva
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12949
Subject(s) - phlebotomy , apheresis , medicine , blood volume , hematocrit , hemochromatosis , red blood cell , volume overload , adverse effect , urology , surgery , gastroenterology , platelet , heart failure
Background Phlebotomy represents the standard treatment option for iron overload in hemochromatosis ( HC ). Recently, red blood cell ( RBC ) apheresis has increasingly been used to remove iron. In this study we evaluated the depletion program of the newly developed S pectra O ptia device. Study Design and Methods Adult male patients (n = 11) with HC were RBC depleted with the S pectra O ptia device ( T erumo BCT ). In total, 24 procedures were performed. A volume of 300 to 550 mL of RBC s was withdrawn per single treatment. Results No significant adverse events were recorded. A median blood volume of 857.3 ± 23.3 mL was processed. The median procedure time was 12.0 ± 0.4 minutes. The mean reduction of H ct value in each procedure was approximately 6% ( H ct pre 42.6 ± 0.5% vs. H ct post 36.6 ± 0.6%) and iron removed per procedure was 405.2 ± 23.3 mg. Conclusion The S pectra O ptia device proved to be highly efficient in depleting RBCs in HC patients and allows for short procedure time. The O ptia device can be safely used in this clinical setting. We recommend its use in case of severe iron overload if rapid iron depletion needs to be achieved and in case of cardiac compromise due to less blood volume removed.