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Real‐time symptomatic case of transfusion‐transmitted dengue
Author(s) -
Levi José Eduardo,
Nishiya Anna,
Félix Alvina Clara,
Salles Nanci Alves,
Sampaio Luciana Ribeiro,
Hangai Fátima,
Sabino Ester Cerdeira,
Mendrone Alfredo
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12944
Subject(s) - dengue fever , medicine , blood transfusion , plateletpheresis , dengue virus , outbreak , antibody , immunology , virology , platelet , apheresis
Background Dengue virus transmission by blood transfusion is a rarely reported event. Case Report During a dengue outbreak in S ão P aulo city, a regular plateletpheresis donor informed the blood bank of being diagnosed a few days after donation. The recipient was hospitalized and displayed symptoms and laboratory evidence of dengue after transfusion. Results The donor was immunoglobulin ( Ig ) G , IgM , and polymerase chain reaction nonreactive on the index sample, seroconverting 20 days later. The platelet units were transfused into two patients. One of them developed fever 3 days after transfusion, with high viral load. His pretransfusion sample was negative for IgG , IgM , and dengue RNA , while the second recipient did not show any symptoms nor laboratory evidence of dengue infection. Conclusions This case brings additional evidence that dengue is indeed transmissible by blood transfusion and clinical manifestations, although rare, do occur.