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The proportion and trend of human immunodeficiency virus infections associated with men who have sex with men from C hinese voluntary blood donors: a systematic review and meta‐analysis
Author(s) -
Lu Jinxin,
Xu Junjie,
Reilly Kathleen Heather,
Li Yongze,
Zhang Christiana Meng,
Jiang Yongjun,
Geng Wenqing,
Wang Lunan,
Shang Hong
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12871
Subject(s) - medicine , meta analysis , confidence interval , human immunodeficiency virus (hiv) , demography , blood donor , men who have sex with men , population , immunology , environmental health , syphilis , sociology
Background Human immunodeficiency virus ( HIV )‐positive cases associated with men who have sex with men ( MSM ) have rapidly increased over the past years. The objective of this study is to comprehensively evaluate the proportions, changing trends, and geographical distribution of MSM ‐associated HIV cases from C hinese voluntary blood donors by systematically reviewing the available literature. Study Design and Methods Major E nglish and C hinese research databases were searched for studies reporting study locations, study years, the number of HIV infections among blood donors, and the number of HIV ‐positive donations associated with MSM in C hina. The proportion estimates were calculated; subgroup analyses and test for time trend were performed using software of comprehensive meta‐analysis. Results Thirty‐four studies met eligibility criteria. The pooled proportion of HIV ‐positive donations associated with MSM from 2001 to 2012 was 36.5% (95% confidence interval, 29.6%‐44.1%). The epidemic was found to be more severe in northeast and north C hina compared to south C hina (59.6%; 55.0% vs. 3.8%, respectively). The proportion showed a significantly increasing trend over the study period (10.3% in 2001‐2005; 38.6% in 2006‐2009; and 47.6% in 2010‐2012; trend test chi‐square = 16.42, p < 0.001). Conclusion The relatively high proportion of MSM ‐ associated HIV ‐positive donors is of concern. Efficient and effective measures focused on public education and improving knowledge of blood safety are needed to prevent this at‐risk population from seeking HIV testing through blood donation. It is also imperative to expand the scope of postdonation nucleic acid testing to shorten the window period to improve blood supply safety in C hina.