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Impact of platelet transfusion on toxicity and mortality after hematopoietic progenitor cell transplantation
Author(s) -
Christou Grace,
Kekre Natasha,
Petrcich William,
Tokessy Melanie,
Neurath Doris,
Giulivi Antonio,
Saidenberg Elianna,
McDiarmid Sheryl,
Atkins Harold,
BenceBruckler Isabelle,
Bredeson Christopher,
Huebsch Lothar,
Sabloff Mitchell,
Sheppard Dawn,
Tay Jason,
Tinmouth Alan,
Allan David S.
Publication year - 2015
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12817
Subject(s) - medicine , univariate analysis , hematopoietic stem cell transplantation , platelet transfusion , retrospective cohort study , transplantation , multivariate analysis , blood transfusion , intensive care unit , platelet , toxicity , surgery
Background Thrombocytopenia occurs commonly after hematopoietic progenitor cell transplantation ( HPCT ) and is associated with potential morbidity and mortality. Few studies have examined the impact of platelet ( PLT ) transfusion on clinical outcomes in HPCT while optimal PLT transfusion strategies after HSCT remain uncertain. Study Design and Methods A retrospective single‐center cohort study was conducted on 522 patients undergoing HPCT between J anuary 2002 and D ecember 2007. Associations between PLT transfusion events and clinical characteristics with transplant‐related outcomes were assessed using univariate and multivariate analysis. Results Mean number of PLT transfusion events before D ay +60 posttransplant was 7.5 (95% confidence interval, 6.7‐8.4) with greater number of events after allogeneic compared with autologous HPCT (p < 0.01). Univariate and multivariate analysis confirmed that the number of PLT transfusion events was associated with increased 100‐day nonrelapse mortality (p < 0.01), posttransplant length of hospital stay (p < 0.01), need for intensive care unit admission (p < 0.01), and number of organs affected by severe toxicity (p < 0.01). Conclusion HPCT ‐related toxicity and mortality are associated with increased PLT transfusion events. Alternative strategies to reduce PLT transfusions after HPCT may warrant future study.