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Impact of ethnicity on human umbilical cord blood banking: a systematic review
Author(s) -
Akyurekli Celine,
Chan Joshua Y.S.,
Elmoazzen Heidi,
Tay Jason,
Allan David S.
Publication year - 2014
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12630
Subject(s) - umbilical cord , cord blood , ethnic group , medicine , haematopoiesis , cord , obstetrics , surgery , immunology , stem cell , biology , political science , law , genetics
Background How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear. Study Design and Methods After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units. Results Non‐ C aucasian ethnicity of the cord blood donor was associated with a higher risk of failing to meet banking criteria, lower cord blood volume, reduced total nucleated cell count, fewer CD 34+ cells, and reduced colony‐forming units. Conclusions Non‐ C aucasian ethnicity is associated with reductions in hematopoietic measures of collected cord blood units. Public banking efforts will have to balance issues related to building ethnic diversity within the bank and maintaining the characteristics of banked units that remain desirable by transplant centers.