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Effect of maternal iron status on the number of CD 34+ stem cells harvested from umbilical cord blood
Author(s) -
Pope Belinda,
Hokin Bevan,
Grant Ross
Publication year - 2014
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12547
Subject(s) - umbilical cord , cd34 , andrology , haematopoiesis , cord blood , stem cell , medicine , immunology , iron status , progenitor cell , white blood cell , ferritin , physiology , iron deficiency , biology , anemia , genetics
Background Hematopoietic progenitor cells ( HPCs ) from umbilical cord blood ( UCB ) are an alternative source of stem cells. However an adequate number of HPCs must be harvested from each UCB sample to make therapeutic applications possible. This study investigated the impact of selected maternal indices (in particular iron status) on the number of CD 34+ cells collected in the UCB . Study Design and Methods Blood samples were collected from 91 matched mother and umbilical cord pairs and analyzed for full blood count, iron status, and C ‐reactive protein. Viable CD 34 enumeration was performed on the cord blood samples. Results Low CD 34+ cell counts were associated with higher maternal serum ferritin ( SF ), older mothers, lower UCB white blood cell count ( WCC ), lower UCB nucleated red blood cells ( NRBCs ), and lower birthweight. Maternal SF correlated with maternal variables of iron status and RBC indices, newborn weight, placental weight, and NRBCs /100 WCC . Conclusion This study indicates that lower numbers of CD 34+ cells are more likely to occur when collected from mothers with higher SF . This finding suggests that maternal SF and associated iron status play a significant, but as yet undefined, role in the generation of CD 34+ cells in UCB .