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Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US hemovigilance reporting system
Author(s) -
Li Ning,
Williams Lawrence,
Zhou Zhiming,
Wu YanYun
Publication year - 2014
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12520
Subject(s) - medicine , incidence (geometry) , platelet transfusion , pediatrics , retrospective cohort study , emergency medicine , intensive care medicine , platelet , physics , optics
Background Transfusion reactions in pediatric populations have not been well studied. We investigated the incidence and type of transfusion reactions to platelets ( PLTs ) in a pediatric inpatient population. Study Design and Methods Over 1 year, a retrospective review of all PLT transfusions given to pediatric inpatients (≤18 years old) was performed at a single institution with application of the US hemovigilance reporting definitions. Intraoperative transfusions were excluded. Any signs or symptoms that could represent an acute transfusion reaction ( ATR ) within 24 hours after PLT transfusion were reviewed and classified based on the US hemovigilance reporting definitions. Results Between J une 1, 2010, and M ay 31, 2011, a total of 805 PLT transfusions to 126 patients were identified as appropriate for inclusion. Of these 805 transfusions, 116 (14.4%) met the reporting criteria for ATR s. Some PLT transfusions were associated with multiple types of ATR s leading to 120 ATR s overall, as defined by the US hemovigilance reporting system. Of these 120 reportable ATR s, 54 (45.0%) transfusion‐associated dyspnea ( TAD ) reactions, 38 (31.7%) febrile nonhemolytic transfusion reactions, 15 (12.5%) allergic transfusion reactions, eight (6.7%) hypotensive transfusion reactions, and five (4.2%) transfusion‐associated cardiac overload reactions were identified. No resultant deaths associated with ATR s were observed. Of these reportable ATR s, only four (3.34%) were reported to the hospital transfusion service. Conclusions Our findings indicate that reportable ATR s in the pediatric populations may be more prevalent than previously reported and were underreported to our transfusion service. TAD encompassed the majority of reportable ATR s and is the main contributor to the increased rate of reportable ATR s.