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Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
Author(s) -
Shigemura Tomonari,
Nakazawa Yozo,
Yoshikawa Kentaro,
Hirabayashi Koichi,
Saito Shoji,
Kobayashi Norimoto,
Sakashita Kazuo,
Shiohara Masaaki,
Wada Taizo,
Shimodaira Shigetaka,
Agematsu Kazunaga,
Koike Kenichi
Publication year - 2014
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12325
Subject(s) - chronic granulomatous disease , medicine , micafungin , voriconazole , aspergillosis , immunology , cord blood , transplantation , aspergillus fumigatus , antifungal , dermatology
Background: Chronic granulomatous disease ( CGD ) is a rare inherited primary immunodeficiency that affects phagocytic cells. CGD patients are susceptible to fungal infections, especially Aspergillus infections. The management of life‐threatening Aspergillus infections in CGD is particularly difficult because some infections cannot be eradicated with standard antifungal treatments and, hence, result in death. Case Report: A 2‐week‐old girl developed invasive pulmonary aspergillosis, which rapidly progressed to respiratory failure. Liposomal amphotericin B, micafungin, and voriconazole were not effective. At the age of 2 months, she was diagnosed with p67phox‐deficient CGD . In addition to antifungal treatment, the patient received 21 granulocyte transfusions ( GTX ), which were obtained from 300‐ or 400‐ mL whole blood samples from healthy random donors who were not treated with granulocyte–colony‐stimulating factor or dexamethasone. The median neutrophil count of the GTX was 1.88 × 10 8 /kg body weight. Rituximab was administered to reduce alloimmunization to human leukocyte antigens ( HLA ) after the eighth GTX , resulting in their absence of anti‐ HLA before and after cord blood transplantation ( CBT ). A marked improvement in her invasive pulmonary aspergillosis was achieved, although the first CBT was rejected. Complete hematopoietic recovery was obtained after the second CBT . Conclusion: Repeated GTX containing relatively low doses of neutrophils might be able to control severe Aspergillus infections in infants with CGD .