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Interleukin‐28 B genetic variations and spontaneous clearance of hepatitis C antibody–positive blood donors in C hina
Author(s) -
Liu Yu,
Ma Hongli,
Chen Shanhua,
Wang Jingxing,
Liu Gui,
Xu Min,
Ke Ling,
He Miao
Publication year - 2013
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12305
Subject(s) - genotype , hepatitis c virus , immunology , antibody , single nucleotide polymorphism , virology , allele , hepatitis c , biology , medicine , gene , virus , genetics
Background Single‐nucleotide polymorphisms ( SNPs ) near the interleukin ( IL )28 B gene have been shown to be associated with spontaneous clearance of hepatitis C virus ( HCV ) infection in western populations. Anti‐ HCV –reactive and HCV RNA –negative samples were often found in C hinese blood donors. This study was to determine whether the IL 28 B gene variant is also associated with the natural outcome of HCV infection in C hinese blood donors. Study Design and Methods A total of 111 anti‐ HCV –negative blood donors and 100 anti‐ HCV –reactive subjects were enrolled in this study. HCV ‐infected blood donors were classified into spontaneous clearance group and chronic infection group through HCV RNA detection. IL 28 B genetic variations (rs8099917 and rs12979860) were genotyped by polymerase chain reaction and direct sequencing. Results A total of 24 (24.0%) donors spontaneously cleared HCV . The rs12979860 C allele frequency was 90.3% and the rs8099917 T allele frequency was 96.7% in our study. The rs12979860 CC genotype was strongly associated with spontaneous HCV clearance. Female blood donors had a higher rate of spontaneous HCV clearance than male donors (15/42 [35.7%] vs. 9/58 [15.5%], p = 0.02). Conclusions The rs12979860 CC variant upstream of IL 28 B gene is associated with spontaneous clearance of HCV in C hinese blood donors and female donors are more likely to clear HCV infection than male donors.