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The evolving role of lyophilized plasma in remote damage control resuscitation in the F rench A rmed F orces H ealth S ervice
Author(s) -
Sailliol Anne,
Martinaud Christophe,
Cap Andrew P.,
Civadier Corinne,
Clavier Benoit,
Deshayes AnneVirginie,
Mendes AnneChristine,
Pouget Thomas,
Demazeau Nicolas,
Chueca Marine,
Martelet FrançoisRégis,
Ausset Sylvain
Publication year - 2013
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/trf.12038
Subject(s) - hemostasis , medicine , resuscitation , blood product , context (archaeology) , whole blood , blood transfusion , emergency medicine , intensive care medicine , surgery , biology , paleontology
Freeze‐dried plasma was developed by the US A rmy for the resuscitation of combat casualties during W orld W ar II. The French Military Blood Institute began producing French lyophilized plasma ( FLYP ) in 1949, in accordance with F rench blood product guidelines. Since 2010, a photochemical pathogen inactivation process has been implemented to reduce the remaining transfusion‐related infectious risk. All quality controls for this procedure verify that the hemostatic properties of FLYP are conserved. FLYP is compatible with all blood types, can be stored at room temperature for 2 years, and its reconstitution requires less than 6 minutes. As a result, FLYP allows quick delivery of all the coagulation proteins and the application of a 1:1 ratio of FLYP and red blood cells in the context of a massive transfusion. Hemovigilance data collected in F rance since 1994 have included FLYP . Results indicate no reporting of infection related to the use of FLYP . Clinical monitoring with a focus on hemostasis was implemented in 2002 and expanded in 2010. The data, obtained from overseas operations, confirmed the indications, the safety and the clinical efficacy of FLYP . Further research is needed to determine specific indications for FLYP in the therapeutic management of civilian patients with severe hemorrhage.