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Endocytosis, cadherins and tissue dynamics
Author(s) -
KatsunoKambe Hiroko,
Yap Alpha S.
Publication year - 2020
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12721
Subject(s) - endocytosis , cadherin , biology , microbiology and biotechnology , receptor mediated endocytosis , morphogenesis , adhesion , dynamics (music) , receptor , genetics , cell , chemistry , sociology , gene , pedagogy , organic chemistry
By happy chance, the founding of Traffic in 1999 coincided with a clutch of reports that documented the endocytosis and recycling of classical cadherin adhesion receptors. This stimulated a concerted effort to elucidate the molecular regulation of cadherin endocytosis and to identify its functional implications. In particular, endocytosis provided new perspectives to understand how cadherins are modulated during tissue morphogenesis. In this short article, we consider some of what we have learnt about this problem and identify open questions for future research.