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Lysosomal size matters
Author(s) -
Araujo Mariana E. G.,
Liebscher Gudrun,
Hess Michael W.,
Huber Lukas A.
Publication year - 2020
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12714
Subject(s) - biology , microbiology and biotechnology , lysosome , organelle , homeostasis , catabolism , extracellular , metabolism , biochemistry , enzyme
Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra‐ and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.