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COPII‐mediated trafficking at the ER/ERGIC interface
Author(s) -
Peotter Jennifer,
Kasberg William,
Pustova Iryna,
Audhya Anjon
Publication year - 2019
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12654
Subject(s) - copii , endoplasmic reticulum , microbiology and biotechnology , copi , biology , golgi apparatus , endomembrane system , biogenesis , vesicular transport proteins , secretory pathway , transport protein , compartment (ship) , endosome , biochemistry , gene , oceanography , vacuolar protein sorting , geology , intracellular
Coat proteins play multiple roles in the life cycle of a membrane‐bound transport intermediate, functioning in lipid bilayer remodeling, cargo selection and targeting to an acceptor compartment. The Coat Protein complex II (COPII) coat is known to act in each of these capacities, but recent work highlights the necessity for numerous accessory factors at all stages of transport carrier existence. Here, we review recent findings that highlight the roles of COPII and its regulators in the biogenesis of tubular COPII‐coated carriers in mammalian cells that enable cargo transport between the endoplasmic reticulum and ER‐Golgi intermediate compartments, the first step in a series of trafficking events that ultimately allows for the distribution of biosynthetic secretory cargoes throughout the entire endomembrane system.