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RNA localization regulates diverse and dynamic cellular processes
Author(s) -
Ryder Pearl V.,
Lerit Dorothy A.
Publication year - 2018
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12571
Subject(s) - biology , microbiology and biotechnology , rna , messenger rna , subcellular localization , translation (biology) , protein subcellular localization prediction , rna binding protein , cytoplasm , genetics , gene
RNA localization is a fundamental paradigm used to compartmentalize gene activity within diverse cellular contexts. When coupled to translational control, the localization of messenger RNA (mRNA) generates localized protein enrichments within cells. Long appreciated for its role in neurogenesis and embryo development, RNA localization is evolutionarily conserved across taxa and contributes to a myriad of cellular responses, including polarization, adhesion, migration, proliferation, host‐pathogen interactions, the stress response and more. Here, we summarize the importance of mRNA localization to diverse cellular responses referencing several well‐studied models. We conclude that RNA localization is a widespread and conserved mechanism that generates localized protein enrichments with far‐reaching consequences for cellular activity and function