Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport | Zendy

Del Bel Lauren M. | Zendy; Brill Julie A. | Zendy

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Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport

Author(s) -

Del Bel Lauren M.,

Brill Julie A.

Publication year - 2018

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12554

Subject(s) - biology , microbiology and biotechnology , vesicular transport protein , phosphatase , interface (matter) , phosphorylation , genetics , biochemistry , vesicle , pulmonary surfactant , gibbs isotherm , membrane

The lipid phosphatase Sac1 was identified more than 25 years ago in a yeast genetic screen. Since then, investigators have learned much about its roles in the cell. In this review, we present our current understanding of Sac1 structure, regulation and function, and we describe how Sac1—as a phosphatidylinositol 4‐phosphatase—plays multifaceted roles in membrane homeostasis, vesicular and nonvesicular transport, cell signaling, development and disease.

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