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Sac1, a lipid phosphatase at the interface of vesicular and nonvesicular transport
Author(s) -
Del Bel Lauren M.,
Brill Julie A.
Publication year - 2018
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12554
Subject(s) - biology , microbiology and biotechnology , phosphatidylinositol , cell signaling , phosphatase , signal transduction , cell membrane , membrane contact site , cell , membrane , membrane protein , biochemistry , phosphorylation , integral membrane protein
The lipid phosphatase Sac1 was identified more than 25 years ago in a yeast genetic screen. Since then, investigators have learned much about its roles in the cell. In this review, we present our current understanding of Sac1 structure, regulation and function, and we describe how Sac1—as a phosphatidylinositol 4‐phosphatase—plays multifaceted roles in membrane homeostasis, vesicular and nonvesicular transport, cell signaling, development and disease.