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Sorting without a Golgi complex
Author(s) -
Touz Maria C.,
Zamponi Nahuel
Publication year - 2017
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12500
Subject(s) - golgi apparatus , biology , secretory pathway , endoplasmic reticulum , microbiology and biotechnology , sorting , protein targeting , transport protein , giardia lamblia , organelle , secretory protein , copi , secretion , computational biology , membrane protein , genetics , biochemistry , membrane , computer science , programming language
The endoplasmic reticulum‐Golgi‐target organelle route is one of the most studied events and has fascinated researchers for years. However, the conservative mechanism of protein sorting and delivery is now being challenged by the finding of unconventional pathways driving protein sorting and transport. Protozoa parasites are being rediscovered as good models for analyzing alternative targeting pathways, associated with their ability to adapt to diverse environments and hosts. Here, we have gathered all the available information about secretory protein trafficking in Giardia lamblia , with a focus on how this protozoan parasite is able to sort and direct proteins to different compartments in the absence of a Golgi complex.