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Recent progress in autophagic lysosome reformation
Author(s) -
Chen Yang,
Yu Li
Publication year - 2017
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12484
Subject(s) - autophagy , lysosome , microbiology and biotechnology , biology , biochemistry , enzyme , apoptosis
Autophagic lysosome reformation ( ALR ) is the terminal step of autophagy and is essential for maintaining lysosome homeostasis during autophagy. During ALR , tubules are extruded from autolysosomes, and small vesicles named proto‐lysosomes, which are composed of lysosomal membrane components, are generated from these tubules. Eventually, proto‐lysosomes mature into functional lysosomes. In this review, we will summarize recent progress in understanding the regulation, mechanisms and physiological functions of ALR .