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An antimicrobial origin of transit peptides accounts for early endosymbiotic events
Author(s) -
Wollman FrancisAndré
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12446
Subject(s) - biology , endosymbiosis , cytosol , organelle , chloroplast , antimicrobial peptides , internalization , antimicrobial , mitochondrion , transit peptide , microbiology and biotechnology , biochemistry , cell , plastid , gene , enzyme
Primary endosymbiosis, which gave rise to mitochondria or chloroplasts, required successful targeting of a number of proteins from the host cytosol to the endosymbiotic organelles. A survey of studies published in separate fields of biological research over the past 40 years argues for an antimicrobial origin of targeting peptides. It is proposed that mitochondria and chloroplast derive from microbes that developed a resistance strategy to antimicrobial peptides that consisted in their rapid internalization and proteolytic disposal by microbial peptidases.