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HIV ‐1 Nef: Taking Control of Protein Trafficking
Author(s) -
Pereira Estela A.,
daSilva Luis L. P.
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12412
Subject(s) - biology , endocytic cycle , microbiology and biotechnology , viral replication , viral life cycle , cell , intracellular , human immunodeficiency virus (hiv) , infectivity , virus , viral pathogenesis , virology , endocytosis , genetics
The Nef protein of the human immunodeficiency virus modifies the surface proteome of infected cells in order to create an optimized environment for viral replication and to enhance the infectivity of newly produced virions. Nef achieves this goal by hijacking membrane trafficking pathways to keep specific immune receptors, signaling molecules and viral restriction factors away from the plasma membrane. This review focuses on how Nef interferes with protein trafficking by physically linking target surface proteins to components of protein sorting machinery.