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N‐Cadherin Regulates Cell Migration Through a Rab5‐Dependent Temporal Control of Macropinocytosis
Author(s) -
Wen MengHsuan,
Wang JenYeu,
Chiu YuTing,
Wang MeiPin,
Lee SuePing,
Tai ChinYin
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12402
Subject(s) - pinocytosis , endocytic cycle , microbiology and biotechnology , endocytosis , endosome , biology , cell migration , cell , intracellular , biochemistry
Macropinocytosis is a clathrin‐independent endocytic pathway implicated in cell migration. We show that lateral clustering of N‐cadherin (Ncad) forms specialized micro‐domains involved in the recruitment of Rab5 at the macropinosomes. De‐clustering of Ncad drives Rab5‐to‐Rab7 conversion and promotes macropinosome maturation. Consequently, both centripetal trafficking of macropinosomes and wound‐induced migration are accelerated. These results suggest a new role for Ncad in cell migration through temporal control of macropinocytosis.