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Differential Use of the C‐Type Lectins L‐ SIGN and DC‐SIGN for Phlebovirus Endocytosis
Author(s) -
Léger Psylvia,
Tetard Marilou,
Youness Berthe,
Cordes Nicole,
Rouxel Ronan N.,
Flamand Marie,
Lozach PierreYves
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12393
Subject(s) - phlebovirus , dc sign , biology , endocytic cycle , endocytosis , virology , internalization , virus , bunyaviridae , viral entry , microbiology and biotechnology , receptor , dendritic cell , viral replication , antigen , immunology , genetics
The receptors and cellular factors used by phleboviruses ( Bunyaviridae ) to enter host cells remain largely unidentified. In addition to the C‐type lectin DC‐SIGN (Dendritic cell‐specific intercellular adhesion molecule 3‐grabbing non‐integrin), we report here that several phleboviruses subvert the closely related protein L‐ SIGN for infection. Together, our results establish that L‐ SIGN is an attachment factor not required for virus internalization whereas DC‐SIGN is an authentic entry receptor required for both binding and endocytosis. Our study underlines the importance of the subsequent entry processes in virus–receptor interactions beyond attachment.