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Fusion of Enveloped Viruses in Endosomes
Author(s) -
White Judith M.,
Whittaker Gary R.
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12389
Subject(s) - endosome , lipid bilayer fusion , microbiology and biotechnology , biology , viral envelope , endocytic cycle , viral entry , fusion mechanism , proteases , escrt , endocytosis , virology , intracellular , receptor , virus , biochemistry , viral replication , enzyme
To initiate infection, enveloped viruses must fuse with a cell membrane, a process mediated by a dedicated viral fusion protein. To date, these proteins group into three basic structural classes. Most require priming (via a protease) to prepare them to respond to a fusion‐triggering signal. Known fusion triggers include receptors, low pH and proteases (and combinations thereof). Here, we provide an update on viral fusion protein priming and triggering, with a focus on virus fusion in endosomes.