Fusion of Enveloped Viruses in Endosomes | Zendy

White Judith M. | Zendy; Whittaker Gary R. | Zendy

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Fusion of Enveloped Viruses in Endosomes

Author(s) -

White Judith M.,

Whittaker Gary R.

Publication year - 2016

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12389

Subject(s) - endosome , lipid bilayer fusion , microbiology and biotechnology , biology , viral envelope , endocytic cycle , viral entry , fusion mechanism , proteases , escrt , endocytosis , virology , intracellular , receptor , virus , biochemistry , viral replication , enzyme

To initiate infection, enveloped viruses must fuse with a cell membrane, a process mediated by a dedicated viral fusion protein. To date, these proteins group into three basic structural classes. Most require priming (via a protease) to prepare them to respond to a fusion‐triggering signal. Known fusion triggers include receptors, low pH and proteases (and combinations thereof). Here, we provide an update on viral fusion protein priming and triggering, with a focus on virus fusion in endosomes.

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