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Principles of Virus Uncoating: Cues and the Snooker Ball
Author(s) -
Yamauchi Yohei,
Greber Urs F.
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12387
Subject(s) - biology , virus , microbiology and biotechnology , viral replication , viral entry , capsid , innate immune system , virology , immune system , genetics
The architecture of a virus particle allows timely release of the viral genome in a host cell during entry. This critical step is known as viral uncoating. It is regulated by cues from receptors, enzymes and chemicals, and facilitated by factors that do not contact the virion directly. This review covers a wide range of cellular processes that enhance viral uncoating. The underlying mechanisms provide deep insights into cell biological and immunological processes of virus–host interactions and infections.