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Engineered Tug‐of‐War Between Kinesin and Dynein Controls Direction of Microtubule Based Transport In Vivo
Author(s) -
Rezaul Karim,
Gupta Dipika,
Semenova Irina,
Ikeda Kazuho,
Kraikivski Pavel,
Yu Ji,
Cowan Ann,
Zaliapin Ilya,
Rodionov Vladimir
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12385
Subject(s) - dynein , microtubule , kinesin , organelle , dynactin , biology , microbiology and biotechnology , motor protein , molecular motor , tug of war , physics , astronomy
Recruitment of external plus‐end directed microtubule motor kinesin‐1 to the surface of pigment granules transported to microtubule minus‐ends by cytoplasmic dynein in melanophores creates a tug‐of‐war between opposing microtubule motors in vivo . Loading with kinesin‐1 attenuates minus‐end directed runs of pigment granules generated by dynein, and reverses the overall direction of their movement. Therefore, in the absence of external signals, a tug‐of‐war between opposing microtubule motors is sufficient to control the directionality of microtubule transport in vivo .