Engineered Tug‐of‐War Between Kinesin and Dynein Controls Direction of Microtubule Based Transport  In Vivo | Zendy

Rezaul Karim | Zendy; Gupta Dipika | Zendy; Semenova Irina | Zendy; Ikeda Kazuho | Zendy; Kraikivski Pavel | Zendy; Yu Ji | Zendy; Cowan Ann | Zendy; Zaliapin Ilya | Zendy; Rodionov Vladimir | Zendy

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Engineered Tug‐of‐War Between Kinesin and Dynein Controls Direction of Microtubule Based Transport In Vivo

Author(s) -

Rezaul Karim,

Gupta Dipika,

Semenova Irina,

Ikeda Kazuho,

Kraikivski Pavel,

Yu Ji,

Cowan Ann,

Zaliapin Ilya,

Rodionov Vladimir

Publication year - 2016

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12385

Subject(s) - dynein , microtubule , kinesin , organelle , dynactin , biology , microbiology and biotechnology , motor protein , molecular motor , tug of war , physics , astronomy

Recruitment of external plus‐end directed microtubule motor kinesin‐1 to the surface of pigment granules transported to microtubule minus‐ends by cytoplasmic dynein in melanophores creates a tug‐of‐war between opposing microtubule motors in vivo . Loading with kinesin‐1 attenuates minus‐end directed runs of pigment granules generated by dynein, and reverses the overall direction of their movement. Therefore, in the absence of external signals, a tug‐of‐war between opposing microtubule motors is sufficient to control the directionality of microtubule transport in vivo .

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