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Space: A Final Frontier for Vacuolar Pathogens
Author(s) -
Case Elizabeth Di Russo,
Smith Judith A.,
Ficht Thomas A.,
Samuel James E.,
de Figueiredo Paul
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12382
Subject(s) - biology , intracellular , vacuole , microbiology and biotechnology , intracellular parasite , pathogen , cytoplasm
Intracellular bacteria must appropriate host vesicular traffic and membrane fusion events to build pathogen‐specific niches. Here, we review the molecular mechanisms and trafficking pathways that drive two space allocation strategies of intracellular bacteria, the formation of tight and spacious pathogen‐containing vacuoles. We relate bacterial modulation of vacuolar space to its impact on critical facets of intracellular parasitism and discuss the evolutionary drivers that may have shaped their replicative vacuoles.