Premium
Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3
Author(s) -
Li Caiyue,
Ma Wenbo,
Yin Shikui,
Liang Xin,
Shu Xiaodong,
Pei Duanqing,
Egan Terrance M.,
Huang Jufang,
Pan Aihua,
Li Zhiyuan
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12379
Subject(s) - sorting nexin , microbiology and biotechnology , biology , hacat , transfection , endosome , transport protein , leupeptin , membrane protein , hek 293 cells , lysosome , cell culture , biochemistry , receptor , membrane , in vitro , intracellular , genetics , protease , enzyme
The trafficking of ion channels to/from the plasma membrane is essential for the functionality of cells. We report the novel finding that the vesicular trafficking protein SNX11 promotes the trafficking of exogenous TRPV3 ion channel from the plasma membrane to lysosome for degradation via protein–protein interactions in HEK293T cells, and it also decreases the level of endogenous TRPV3 protein in human skin keratinocytes HaCaT cells, which leads to a change in the density of TRPV3 channels on the cell surface.