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The Na + ‐Taurocholate Cotransporting Polypeptide Traffics with the Epidermal Growth Factor Receptor
Author(s) -
Wang Xintao,
Wang Pijun,
Wang Wenjun,
Murray John W.,
Wolkoff Allan W.
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12354
Subject(s) - epidermal growth factor receptor , biology , microbiology and biotechnology , vesicle , epidermal growth factor , colocalization , intracellular , motility , gene knockdown , receptor , growth factor receptor , signal transduction , biochemistry , apoptosis , membrane
Na + ‐taurocholate cotransporting polypeptide (ntcp) mediates bile acid transport, also serving as the hepatitis B virus receptor. It traffics in vesicles along microtubules, requiring activity of protein kinase C ( PKC )ζ for motility. We have now found that the epidermal growth factor receptor ( EGFR ) is the target of PKCζ activity and that EGFR and ntcp colocalize in vesicles. ntcp‐containing vesicles that are not associated with EGFR have reduced microtubule‐based motility, consistent with intracellular accumulation and reduced surface expression of ntcp in cells following EGFR knockdown.