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Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal–Placental Messaging
Author(s) -
Holder Beth,
Jones Tessa,
Sancho Shimizu Vanessa,
Rice Thomas F.,
Donaldson Beverly,
Bouqueau Marielle,
Forbes Karen,
Kampmann Beate
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12352
Subject(s) - microvesicles , biology , macrophage , microbiology and biotechnology , inflammation , placenta , proinflammatory cytokine , immunology , microrna , pregnancy , genetics , gene , fetus , in vitro
Exosome trafficking from the placenta into the maternal circulation is well documented; the possibility that this trafficking is bi‐directional was unknown. We demonstrated clathrin‐mediated endocytosis of macrophage exosomes by the human placenta. We also demonstrated that macrophage exosomes induced placental production of cytokines interleukin ( IL )‐6, IL ‐8 and IL ‐10. Exosomes therefore comprise an additional mechanism of immune cell signalling to the placenta, potentially facilitating protective responses to maternal inflammation and infection in pregnancy. This represents a novel mode of maternal–placental messaging.