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Phosphorylation of αSNAP is Required for Secretory Organelle Biogenesis in Toxoplasma gondii
Author(s) -
Stewart Rebecca J.,
Ferguson David J. P.,
Whitehead Lachlan,
Bradin Clare H.,
Wu Hong J.,
Tonkin Christopher J.
Publication year - 2016
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12348
Subject(s) - microbiology and biotechnology , biology , organelle biogenesis , biogenesis , organelle , toxoplasma gondii , golgi apparatus , secretory pathway , secretory vesicle , phosphorylation , transport protein , secretory protein , endocytic cycle , secretion , exocytosis , endoplasmic reticulum , cell , biochemistry , endocytosis , genetics , antibody , gene
The authors show that phosphorylation of α SNAP , a protein required for turnover of SNARE complexes after vesicle fusion, is important for secretory pathway protein trafficking and organelle biogenesis in Toxoplasma gondii . This work therefore highlights a potential mechanism of regulation of secretory pathway biogenesis during growth in this important pathogen.