Distinct Trafficking of Cell Surface and Endosomal  TIM ‐1 to the Immune Synapse | Zendy

Echbarthi Meriem | Zendy; Zonca Manuela | Zendy; Mellwig Rachel | Zendy; Schwab Yannick | Zendy; Kaplan Gerardo | Zendy; DeKruyff Rosemarie H. | Zendy; RodaNavarro Pedro | Zendy; Casasnovas Jose M. | Zendy

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Distinct Trafficking of Cell Surface and Endosomal TIM ‐1 to the Immune Synapse

Author(s) -

Echbarthi Meriem,

Zonca Manuela,

Mellwig Rachel,

Schwab Yannick,

Kaplan Gerardo,

DeKruyff Rosemarie H.,

RodaNavarro Pedro,

Casasnovas Jose M.

Publication year - 2015

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12329

Subject(s) - immunological synapse , biology , endosome , microbiology and biotechnology , synapse , immune system , t cell , neuroscience , immunology , t cell receptor , intracellular

The T cell costimulatory molecule TIM ‐1 ( T cell/transmembrane, mucin and immunoglobulin domain protein 1) sorts mainly to endosomes in lymphoid cells. At difference from the cell surface protein, endosomal TIM ‐1 translocates to the immune synapse ( IS ), where it can contribute to antigen‐dependent T cell costimulation. TIM ‐1 ligands increase the amount of cell surface protein, preventing its traffic to the IS . The bipolar sorting of TIM ‐1 observed during IS formation is determined by differences in its subcellular location, and probably modulates antigen‐driven immune responses.

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