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Distinct Trafficking of Cell Surface and Endosomal TIM ‐1 to the Immune Synapse
Author(s) -
Echbarthi Meriem,
Zonca Manuela,
Mellwig Rachel,
Schwab Yannick,
Kaplan Gerardo,
DeKruyff Rosemarie H.,
RodaNavarro Pedro,
Casasnovas Jose M.
Publication year - 2015
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12329
Subject(s) - immunological synapse , biology , endosome , microbiology and biotechnology , synapse , immune system , t cell , neuroscience , immunology , t cell receptor , intracellular
The T cell costimulatory molecule TIM ‐1 ( T cell/transmembrane, mucin and immunoglobulin domain protein 1) sorts mainly to endosomes in lymphoid cells. At difference from the cell surface protein, endosomal TIM ‐1 translocates to the immune synapse ( IS ), where it can contribute to antigen‐dependent T cell costimulation. TIM ‐1 ligands increase the amount of cell surface protein, preventing its traffic to the IS . The bipolar sorting of TIM ‐1 observed during IS formation is determined by differences in its subcellular location, and probably modulates antigen‐driven immune responses.