Premium
Inhibitors of Protein Translocation Across the ER Membrane
Author(s) -
Kalies KaiUwe,
Römisch Karin
Publication year - 2015
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12308
Subject(s) - endoplasmic reticulum , biology , cytosol , microbiology and biotechnology , secretion , transport protein , chromosomal translocation , secretory protein , membrane protein , biochemistry , membrane , gene , enzyme
Protein translocation into the endoplasmic reticulum ( ER ) constitutes the first step of protein secretion. ER protein import is essential in all eukaryotic cells and is particularly critical in fast‐growing tumour cells. Thus, the process can serve as target both for potential cancer drugs and for bacterial virulence factors. Inhibitors of protein transport across the ER membrane range from broad‐spectrum to highly substrate‐specific and can interfere with virtually any stage of this multistep process, and even with transport of endocytosed antigens into the cytosol for cross‐presentation.