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Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture
Author(s) -
Alterio Jeanine,
Masson Justine,
Diaz Jorge,
Chachlaki Konstantina,
Salman Haysam,
Areias Julie,
Al Awabdh Sana,
Emerit Michel Boris,
Darmon Michèle
Publication year - 2015
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12306
Subject(s) - golgi apparatus , microbiology and biotechnology , biology , compartment (ship) , hippocampal formation , intracellular , transport protein , neuroscience , endoplasmic reticulum , oceanography , geology
When expression of the vesicular membrane‐bound protein Yif1B is transiently inhibited, VSVG traffics faster toward the Golgi and the plasma membrane. With Yif1B long term depletion, like in Yif1B KO mice, acceleration of VSVG trafficking in hippocampal neurons is also observed, together with an increased fragmentation of the Golgi ribbons into stacks composed of shorter and wider cisternae. Thus, Yif1B plays a role at two cellular levels: in the anterograde traffic of cargo proteins and in Golgi structure maintenance.