Dengue Virus Uses a Non‐Canonical Function of the Host  GBF1 ‐Arf‐ COPI  System for Capsid Protein Accumulation on Lipid Droplets | Zendy

Iglesias Nestor G. | Zendy; Mondotte Juan A. | Zendy; Byk Laura A. | Zendy; De Maio Federico A. | Zendy; Samsa Marcelo M. | Zendy; Alvarez Cecilia | Zendy; Gamarnik Andrea V. | Zendy

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Dengue Virus Uses a Non‐Canonical Function of the Host GBF1 ‐Arf‐ COPI System for Capsid Protein Accumulation on Lipid Droplets

Author(s) -

Iglesias Nestor G.,

Mondotte Juan A.,

Byk Laura A.,

De Maio Federico A.,

Samsa Marcelo M.,

Alvarez Cecilia,

Gamarnik Andrea V.

Publication year - 2015

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12305

Subject(s) - copi , capsid , biology , golgi apparatus , microbiology and biotechnology , dengue virus , endoplasmic reticulum , virology , viral replication , virus , dengue fever , lipid droplet , secretory pathway

The dengue virus capsid protein accumulates progressively around cellular organelles named lipid droplets ( LDs ) during infection. Using different methods of intervention, we defined that capsid transport from virally modified endoplasmic reticulum ( ER ) membranes to LDs requires a functional GBF1 protein. The process was found to be COPI dependent, while it was independent of both COPII components and Golgi integrity, supporting a non‐canonical function of GBF1 / ARF / COPI transport system.

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