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Issue Cover (July 2015)
Publication year - 2015
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12296
Subject(s) - endosome , endocytic cycle , microbiology and biotechnology , biology , golgi apparatus , sted microscopy , trif , transport protein , endocytosis , biochemistry , intracellular , cell , toll like receptor , receptor , endoplasmic reticulum , innate immune system , laser , physics , stimulated emission , optics
Cover legend: The TLR4 signaling adaptor TRAM localizes to the endocytic‐recycling compartment . The spatial distribution of TRIF‐related adaptor molecule (TRAM) was studied during lipopolysaccharide (LPS) stimulation using fl uorescence recovery after photobleaching (FRAP) and conventional confocal microscopy. Our data suggest that Rab11a may regulate LPS induced interferon‐β production through its ability to facilitate TRAM transport form the Golgi to endocytic recycling compartment (ERC) and further onto LPS positive endosomes during LPS stimulation. The cover: 3D‐redering of peri‐nuclear TRAM‐YFP (green)‐, Golgi/α‐GM130 (red)‐ and Rab11a‐CFP (white) channels, showing a high degree of overlap of TRAM and Rab11a in the ERC. See Klein et al. Traffic 2015; 16(7):677–690. Read the full article on doi: 10.1111/tra.12274