Recruitment of  VPS33A  to  HOPS  by  VPS16  Is Required for Lysosome Fusion with Endosomes and Autophagosomes | Zendy

Wartosch Lena | Zendy; Günesdogan Ufuk | Zendy; Graham Stephen C. | Zendy; Luzio J. Paul | Zendy

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Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

Author(s) -

Wartosch Lena,

Günesdogan Ufuk,

Graham Stephen C.,

Luzio J. Paul

Publication year - 2015

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12283

Subject(s) - endosome , microbiology and biotechnology , lysosome , biology , lipid bilayer fusion , endocytic cycle , fusion protein , protein targeting , immunoprecipitation , vacuole , vesicular transport proteins , vacuolar protein sorting , intracellular , endocytosis , biochemistry , membrane protein , cell , cytoplasm , recombinant dna , membrane , gene , enzyme

In yeast the homotypic fusion and vacuole protein sorting ( HOPS ) complex is a tether required for vacuole fusion. We show that all proteins of the mammalian HOPS complex are necessary for fusion of lysosomes with endosomes and that recruitment of the Sec1/Munc18 ( SM ) protein VPS33A to the complex via VPS16 is essential for this and for fusion of lysosomes with autophagosomes. Mammalian VPS33B and VIPAR are not required for these fusion events and are not part of the HOPS or the class C core vacuole/endosome tethering ( CORVET ) complexes, but form a separate complex.

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