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Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution
Author(s) -
Hankins Hannah M.,
Baldridge Ryan D.,
Xu Peng,
Graham Todd R.
Publication year - 2015
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12233
Subject(s) - flippase , phosphatidylserine , microbiology and biotechnology , biology , phospholipid scramblase , endoplasmic reticulum , cytosol , membrane contact site , peripheral membrane protein , membrane protein , integral membrane protein , phospholipid , biochemistry , membrane , enzyme
The eukaryotic plasma membrane ( PM ) and internal organelles have unique lipid compositions. However, the mechanisms by which specific lipid species are trafficked to and maintained in specific areas of the cell are poorly understood and constitute an active area of research. Of particular interest is the distribution of the anionic lipid phosphatidylserine ( PS ), which is enriched in the cytosolic leaflet of the PM . This review will discuss how phospholipid flippases, scramblases and PS ‐specific lipid transfer proteins contribute to subcellular PS distribution.