Premium
Legionella pneumophila Subversion of Host Vesicular Transport by SidC Effector Proteins
Author(s) -
Horenkamp Florian A.,
Mukherjee Shaeri,
Alix Eric,
Schauder Curtis M.,
Hubber Andree M.,
Roy Craig R.,
Reinisch Karin M.
Publication year - 2014
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12158
Subject(s) - legionella pneumophila , biology , effector , microbiology and biotechnology , vacuole , transport protein , legionella , flagellum , protein targeting , intracellular , bacteria , membrane protein , genetics , cytoplasm , membrane
Tethering proteins play a key role in vesicular transport, ensuring that cargo arrives at a specific destination. The bacterial effector protein SidC and its paralog SdcA have been described as tethering factors encoded by the intracellular pathogen Legionella pneumophila . Here, we demonstrate that SidC proteins are important for early events unique to maturation of vacuoles containing Legionella and discover monoubiquitination of Rab1 as a new SidC ‐dependent activity. The crystal structure of the SidC N‐terminus revealed a novel fold that is important for function and could be involved in Legionella adaptations to evolutionarily divergent host cells it encounters in natural environments.