A Dynamin Homolog Promotes the Transition from Hemifusion to Content Mixing in Intracellular Membrane Fusion | Zendy

Kulkarni Aditya | Zendy; Alpadi Kannan | Zendy; Sirupangi Tirupataiah | Zendy; Peters Christopher | Zendy

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A Dynamin Homolog Promotes the Transition from Hemifusion to Content Mixing in Intracellular Membrane Fusion

Author(s) -

Kulkarni Aditya,

Alpadi Kannan,

Sirupangi Tirupataiah,

Peters Christopher

Publication year - 2014

Publication title -

traffic

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.677

H-Index - 130

eISSN - 1600-0854

pISSN - 1398-9219

DOI - 10.1111/tra.12156

Subject(s) - dynamin , endocytosis , microbiology and biotechnology , exocytosis , biology , vesicle fusion , lipid bilayer fusion , vacuole , biophysics , membrane , vesicle , biochemistry , cytoplasm , receptor , synaptic vesicle

Dynamin family members have been implicated in exocytosis. Vps1 (the yeast dynamin homolog) mutant vacuoles show decreased fusion and trans ‐Soluble N ‐ethylmaleimide sensitive factor Attachment Protein Receptor ( SNARE ) complex formation but comparable hemifusion relative to wild type. Vps1, through its oligomerization and SNARE ‐domain binding, brings together multiple t‐ SNAREs . This finding uncovers a novel function of Vps1 in coordinating the hemifusion – content mixing transition in yeast vacuole fusion.

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