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EphA2 Signaling Following Endocytosis: Role of Tiam1
Author(s) -
Boissier Pomme,
Chen Jin,
HuynhDo Uyen
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12123
Subject(s) - ephrin , erythropoietin producing hepatocellular (eph) receptor , endocytosis , microbiology and biotechnology , endocytic cycle , endosome , eph receptor a2 , biology , bulk endocytosis , receptor tyrosine kinase , receptor , signal transduction , intracellular , biochemistry
Eph receptors, a complex subfamily of receptor tyrosine kinases, are rapidly endocytosed following ligand‐mediated activation and traffic through endocytic compartments prior to degradation. Here, we depict the trafficking of the angiogenic and tumorigenic EphA2 receptors and show that a part of them are recycled back to the plasma membrane. Our study also demonstrates for the first time that EphA2 retains the capacity to signal in endosomes. In particular, our findings establish Tiam1, a Rac1‐specific GEF , as an important modulator of EphA2 signaling.