Premium
Regulation of the NADPH Oxidase and Associated Ion Fluxes During Phagocytosis
Author(s) -
Nunes Paula,
Demaurex Nicolas,
Dinauer Mary C.
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12115
Subject(s) - nadph oxidase , phagosome , microbiology and biotechnology , biology , respiratory burst , reactive oxygen species , oxidase test , oxidative stress , protein subunit , phagocytosis , biochemistry , enzyme , gene
NADPH oxidase‐mediated production of ROS within phagosomes is an electrogenic process critical for microbial killing and antigen processing. However, mechanisms regulating oxidase targeting and activation at phagosomes are not well understood and differ according to cell type. This review summarizes recent advances revealing prominent roles for PI (3)P, p40 phox , and trafficking of membrane organelles for regulating phagosomal oxidase activity. Additional recent studies have highlighted the importance of intraphagosomal ionic balance including pH , chloride and calcium fluxes for sustaining optimal phagosomal oxidase function.