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KPNB1 , XPO7 and IPO8 Mediate the Translocation of NF‐κB /p65 into the Nucleus
Author(s) -
Liang Peizhou,
Zhang Haiyan,
Wang Guoxin,
Li Suping,
Cong Shujie,
Luo Yingyun,
Zhang Biliang
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12097
Subject(s) - importin , nuclear transport , karyopherin , nuclear localization sequence , biology , microbiology and biotechnology , cell nucleus , nls , cytoplasm , chromosomal translocation , nucleus , gene knockdown , biochemistry , gene
Several members of importin β family members are responsible for p65 import. The most important one is KPNB1 . It interacts with p65 dependent on KPNA2 and NLS of p65, whereas XPO7 and IPO8 binding to p65 is NLS independent. The importin‐p65 complex is dissociated by RanGTP in the nucleus, and p65 is exported by XPO1 .