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Hidden Behind Autophagy: The Unconventional Roles of ATG Proteins
Author(s) -
Bestebroer Jovanka,
V'kovski Philip,
Mauthe Mario,
Reggiori Fulvio
Publication year - 2013
Publication title -
traffic
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.677
H-Index - 130
eISSN - 1600-0854
pISSN - 1398-9219
DOI - 10.1111/tra.12091
Subject(s) - biology , autophagy , microbiology and biotechnology , genetics , apoptosis
The transport pathway of autophagy is characterized by double‐membrane vesicles called autophagosomes, which are formed through the concerted action of the conserved ATG . Until recently it was assumed that ATG proteins were exclusively involved in autophagy. A growing number of studies, however, have revealed that specific ATG proteins have roles beyond their involvement in autophagosome biogenesis. This article reviews this fast expanding new field of the autophagy research.